There is more to it than that. FPM is a factor, I stopped doing this kind of work a few years ago, and can't seam to find my duct calc chart, So I can not tell you any specs on size. But when I did this, I kept velocity higher in some places than others. We slow the velocity down before the air registration to help keep sound levels down. So the beginning of the run is larger and after every take off, supply size reduces... Amazon sells a calculator like the one I always used.
Static pressure average was around .1"WC. 6" is a standard take off for a register unless you need a lot more than what one can provide. Can only suggest taking a class on this to understand or find a guy that can look at you case and size the duct correctly. The above from Amazon helps a lot to do this calc.
Good Luck.

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Static pressure average was around .1"WC. 6" is a standard take off for a register unless you need a lot more than what one can provide. Can only suggest taking a class on this to understand or find a guy that can look at you case and size the duct correctly. The above from Amazon helps a lot to do this calc.
Good Luck.